The developer of protein-based drugs for the treatment of human diseases went public in February, raising $120 million by offering 10 million shares at $12 each. Shares close dtrading on Friady at $12.16 apiece.

The project passed muster with the City's design review board last week but the director of the City's Department of Design, Construction and Land Use has issued a "determination of significance" on the project relating to traffic impacts. The decision means an environmental impact statement will be required.

Zymogenetics also needs to obtain a shoreline permit ands approval from the landmarks commission--because two possibly historic single family homes are slated for demolition--before the Master Use Permit can be issued.

Written comments with regard to the director's decision are being accepted until April 24. They should be mailed to: Department of Design, Construction and Land Use; Attn: Michael Jenkins, Land Use Planner, 700 5th Avenue, Suite 2000; Seattle, Washington 98104-5070.

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