The central district is located between the Ross Island Bridge and Bancroft Street in the middle of the South Waterfront area. Under the agreement, the district will be filled with high rise buildings providing mostly view-rich high-end condominiums that city officials hope will lure the wealthy back from the suburbs, strengthening the tax base and helping the city to afford the public money that will be spent to pay for the necessary infrastructure to move people in and out of the new district. The area also will include a satellite campus for Oregon Health Sciences University, which is landlocked atop Marquam Hill, which rises immediately west of the South Waterfront area. OHSU's existing campus will be connected to the South Waterfront by an aerial tram and the district as a whole will be connected to Downtown by an extension of the city's streetcar line.

Preliminary plans call for 2,700 condominium and apartment units in the 31-acre central district, or 120 units per acre, which is about three-times as dense as the apartment district in Northwest Portland. The condominium towers will rise between 250 feet and 325 feet, making them some of the tallest buildings in Portland. The height is in part in exchange for the extension of the city's public riverfront greenway into the area and in part a way to maximize tax revenue from the condominiums, as the apartments will likely get tax breaks and OHSU's development will not be taxable at all as it is a nonprofit entity.

The agreement outlines $440 million in private investment in direct new building development for the first phase of the three-phase central district agreement and $103 million in public infrastructure projects. At build out, possibly by 2020, the Central District will have received $1.3 billion in private investment, according to the Portland Development Commission, the city's urban renewal agency, which is directing the development and hammering out the necessary agreements.