Hopkins' School of Public Health occupies a spot on Wolfe Street in East Baltimore. Renamed for one of its former Board of Trustees chairmen, New York Mayor Michael R. Bloomberg, the school has occupied the original 360,000-sf building that was constructed at the university's East Campus for its use back in 1928, 12 years after its establishment.

Other construction endeavors between 1967 and 1991 have increased the building's original size. Construction on the "new" 400,000-sf teaching and research locale began in 1994 and was completed in six phases, the designs of which were overseen by architectural firm Ziger Snead. The final 200,000-sf segment, phases V and VI, consists of 260 new offices, eight floors of laboratory space, a coffee shop, an exercise facility and a 350-seat auditorium.