Dreyfus, a mutual fund company founded in 1951 that currently manages $165 billion in more than 200 mutual fund portfolios, is a wholly owned subsidiary for Mellon Financial Corp.

The 2.8-million-sf Grand Central landmark is also home to Barclays Bank, Mitsui, CB Richard Ellis and Gibson Dunn & Crutcher. Retail tenants include Café Centro, Fleet Bank, Godiva and New York Sports Club.

Lately, some of the largest transactions have been recorded in Midtown. In October, the world's largest law firm, Clifford Chance US LLP, inked a deal for 380,000 sf at the Deutsche Bank's former headquarters at 31 West 52nd St. for its headquarters space. Also in October, Dewey Ballantine LLP renewed and expanded into nearly 500,000 sf of office space for its headquarters at 1301 Avenue of the Americas. And Last month, GlobeSt.com reported that retailer Ann Taylor is shopping around for approximately 200,000 sf of space in Midtown.