A portion of the site will ultimately house the headquarters of mental health and social services provider Humanim Inc. Humanim and Gotham Development are the other members of the development group.

American Brewery is located in East Baltimore at 1701 N. Gay St, about three miles from Johns Hopkins University's Homewood Campus and less than two miles from the Inner Harbor. A landmark architectural facility, the property is currently owned by the City Council and the Office of the Mayor. The original development of the complex was completed in 1887, yielding a 63,000-sf bottling plant and 24,000-sf brewhouse. Once SBER completes the redevelopment process, Humanim will make its home in the smaller building and the other structure will be marketed for lease.