Financial terms of the 10-year lease were not disclosed; asking rents at the 20-story, 464,000-square-foot office tower are $90 per square foot. The property, which was built in the 1920s, is owned by AEW Capital Management on behalf of one of its institutional clients.

David L. Hoffman Jr., executive managing director/principal at Colliers ABR, says in a release that AB InBev was drawn to 250 Park by "the building's location within the Midtown business community, proximity to public transportation, financially stable ownership and also the property's ongoing major capital improvement projects including brand new base and supplemental air-conditioning systems. This lease is also important for New York City real estate because it's been too long since we've heard the words 'positive absorption' in Midtown."

The 250 Park space will be the company's functional management office, which was established to facilitate the day-to-day management of the global business under the direction of the global headquarters and center of strategic decision-making based in Belgium, according to Colliers. AB InBev's nearly 300 brands include Budweiser, Stella Artois and Beck's.