The building incorporates smart technology and smart spaces. Patients can complete paperwork remotely and securely before their visits, using mobile phones or computers. Upon arrival, they will receive personalized “smartbands” that provide access to the building and information about their visits and directions to their rooms, using a NewYork-Presbyterian app. The app will also provide access to discharge instructions, test results and video follow-up appointments with physicians.

An angiography suite will combine key imaging technologies used for minimally invasive procedures, including MRI/PET, fluoroscopy, ultrasound, and rotational CT. This will enable clinicians to diagnose, plan, and precisely guide procedures and verify their completeness. The center will also have three linear accelerators, including an MRI-guided linear accelerator for precision radiation treatment of tumors.

The facility will offer 12 operating suites, six radiology procedure rooms, and 11 endoscopic procedure rooms, including an operating room dedicated to breast surgery with mammography and ultrasound equipment.

Decentralized clinical care with stations directly outside private patient rooms have been designed to provide patients easier access to their medical teams. Unlike many institutions, there are no basement treatment areas. The center will be part of the Weill Cornell Medicine's academic medical center. The intention is for patients to benefit from the school's biomedical research with treatments and therapies.

In 2020, the top five-and-a-half floors will house the NewYork-Presbyterian Alexandra Cohen Hospital for Women and Newborns. The 220,000 square-foot maternity hospital within the hospital will offer rooms for neonatal intensive care, labor and delivery, and cesarean sections. It will have operating suites, maternal assessment and treatment rooms, and ultrasound rooms. MRI capabilities and an operating room in its neonatal intensive care unit will also be in the facility.

The center has a green roof, and a blue roof that can detain up to six inches of storm water. It incorporates triple-panel insulated glazing with a slated wood screen. This reduces solar glare, building heat and the need for shades.

The structure was constructed for resiliency in extreme weather events or disruption to city power. Heating equipment, air handling units, emergency generators and other key operational equipment are located on higher floors above potential flood levels.

HOK, Ballinger, and Pei Cobb Freed & Partners, were the building architects. Peter J. Romano and Company is the project manager, and Turner Construction is the construction manager.