Despite a recent softening in lab demand, the future of spaces in the sector remains tied to innovation in biotechnology and gene therapy. At least, according to Daniel Maldonado, managing director of life sciences of the Americas at Unispace, in a recent exclusive Q&A on the subject. According to Maldonado, who has international experience in operations, strategic planning, business development, commercial and contractual analysis in the construction industry, to navigate the current oversupply, many landlords are diversifying their tenant base by leasing space in newly built life sciences projects to traditional office users.

GlobeSt.com: Recent reports state that the cycle of softening lab demand has moderated. Is that something you are noticing? What does the future hold for the life sciences sector and its real estate needs?

Daniel Maldonado: In Future Labs, a recent white paper from Unispace discussing trends in the design and construction of life sciences spaces, we found that the four key forces currently shaping the future of lab design are science, technology, people and the environment. With ongoing advancements in fields such as gene therapy and drug discovery, the demand for sophisticated laboratory environments is likely to continue growing. However, according to JLL’s 2024 Life Sciences Real Estate Perspective and Cluster Analysis report, as of the third quarter of 2024, the availability rate for life sciences space in the United States was 30%, signaling a significant supply glut in the market. Vacancy rates have increased substantially year-over-year in key areas, creating a challenging landscape for developers and tenants alike. If venture capital funding rebounds, it could further stimulate demand for state-of-the-art facilities designed to meet rigorous technical requirements, helping to right-size the current oversupply in the market. Additionally, current macroeconomic trends, including decreasing interest rates and the potential for regulatory reforms or deregulations, are likely to bolster investment in the life sciences sector. These forces could provide much-needed capital for development and innovation, helping to accelerate growth and demand for cutting-edge lab spaces in the coming years.

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GlobeSt.com: What trends are you seeing in the life sciences venture capital space?

Maldonado: Life sciences venture capital is not just on the path to recovering—it's on track for an exciting period of growth. After a temporary slowdown in 2022, there is growing optimism as we approach the end of 2024, with expectations for a surge in deal activity, investment, and value creation. The sector's resilience is evident in its continued progress in high-impact fields like biotechnology, gene therapy, and drug discovery. Major pharmaceutical companies and venture capital funds are now holding significant reserves, positioning the sector for a wave of innovation and funding. This renewed investment and expansion will likely drive demand for specialized lab spaces, helping to absorb the current oversupply and support a more balanced, sustainable growth trajectory for the life sciences real estate market.

GlobeSt.com: What strategies are landlords using to cope with oversupply in the life sciences market?

Maldonado: To navigate the current oversupply, many landlords are diversifying their tenant base by leasing space in newly built life sciences projects to traditional office users. This flexibility allows them to generate revenue while waiting for lab space demand to recover. Additionally, some landlords are designing properties to include flexible spaces that can cater to various kinds of tenants to better ensure steady occupancy and income.

GlobeSt.com: How do interest rates impact the life sciences real estate market?

Maldonado: Lower interest rates in the U.S., expected to decrease gradually towards 2025 as inflation moderates, will significantly reduce borrowing costs for landlords and developers. As borrowing becomes more affordable, developers and landlords will be able to secure favorable lending terms, enabling them to move forward with new construction and expansion projects that were previously stalled due to higher interest rates. This improved access to capital is also likely to attract more private equity and venture capital investment in life sciences real estate, as the sector’s strong growth prospects continue to drive demand for specialized laboratories and research spaces.

As financing improves, attention will shift back to life sciences tenants, reducing the reliance on interim leasing strategies with traditional office users. This change is expected to stabilize the market and help address the oversupply of office space in key areas. Life sciences companies, backed by growing investment and innovation, will secure long-term leases for specialized facilities, leading to reduced vacancy rates and a more balanced market. Ultimately, the combination of lower interest rates and rising demand for life sciences space will support the sector’s recovery and foster a more stable and sustainable real estate environment.

GlobeSt.com: Taking a look at emerging life sciences markets, how is Seattle making a mark on the industry?

Maldonado: Seattle is a market that has firmly established itself as a leading life sciences hub, driven by advancements in biotechnology and increased venture capital funding. Major players like the Fred Hutchinson Cancer Center and companies such as Bristol Myers Squibb and Moderna are expanding their presence in the area. The local market has seen growth due to a strong talent pool and its proximity to research institutions like the University of Washington, a global leader in biomedical research and innovation. Seattle also boasts a robust ecosystem for life sciences startups, supported by a high concentration of venture capital funding. In 2023 alone, the Seattle area saw life sciences venture investments exceed $500 million, a testament to the growing confidence in the region’s potential. With a combination of top-tier academic resources, world-class research centers, and a thriving life sciences community, Seattle is poised for continued growth and remains a key destination for life sciences companies and talent alike.

GlobeSt.com: Are there specific areas in Seattle that are emerging as important for life sciences expansion?

Maldonado: While South Lake Union remains a focal point for biotech innovation, areas like the Eastside and First Hill are also gaining traction for life sciences expansion. These neighborhoods are becoming increasingly attractive due to their access to talent and collaboration opportunities with established research institutions.

In addition, both the Eastside and First Hill are benefiting from increased investments in commercial real estate, with a number of new life sciences developments underway to meet growing demand. As these areas continue to evolve, they are well-positioned to become critical nodes in Seattle’s life sciences ecosystem, further diversifying the city’s offerings and expanding the reach of biotech innovation beyond South Lake Union.

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Natalie Dolce

Natalie Dolce, editor-in-chief of GlobeSt.com, is responsible for working with editorial staff, freelancers and senior management to help plan the overarching vision that encompasses GlobeSt.com, including short-term and long-term goals for the website, how content integrates through the company’s other product lines and the overall quality of content. Previously she served as national executive editor and editor of the West Coast region for GlobeSt.com and Real Estate Forum, and was responsible for coverage of news and information pertaining to that vital real estate region. Prior to moving out to the Southern California office, she was Northeast bureau chief, covering New York City for GlobeSt.com. Her background includes a stint at InStyle Magazine, and as managing editor with New York Press, an alternative weekly New York City paper. In her career, she has also covered a variety of beats for M magazine, Arthur Frommer's Budget Travel, FashionLedge.com, and Co-Ed magazine. Dolce has also freelanced for a number of publications, including MSNBC.com and Museums New York magazine.